Traduction partielle: G.M.
Glob Adv Health Med. 2014 May;3(3):92-101. doi: 10.7453/gahmj.2014.028.
Tendance séculaire du sex-ratio et profils de symptômes chez les enfants avec des troubles du spectre autistique
Baker SM1, Milivojevich A2, Kraycar T3, Holt B4, Gade S5.
- 1Autism360, Scarsdale, New York (Dr Baker), United States.
- 2The Knowledge Management Group, Mississauga, Ontario (Mr Milivojevich), Canada.
- 3East Hampton Union Free School District, New York (Ms Kraycar), United States.
- 4Reingold, Inc, Alexandria, Virginia (Mr Holt), United States.
- 5Autism360, Scarsdale, New York (Ms Gade), United States.
Abstract
An
information technology invention embodied in a website serving the
interests of the autism community was designed to "let the data talk."
By its use, the authors have detected a downward temporal trend in 2013
in the sex ratio of 2431 members of Autism360.org from a yearly average
between 2010 and 2012 of 4.24 to 3.01 in 2013.
Une invention en technologie de l'information incorporée dans un site Web servant les intérêts de la communauté de l'autisme a été conçue pour «laisser parler de données."
Par son utilisation, les auteurs ont détecté une tendance temporelle à la baisse en 2013 dans le rapport de masculinité de 2431 membres de Autism360.org d'une moyenne annuelle de 04.24 entre 2010 et 2012 à 03.01 en 2013.
As of the first two months of 2014, the average sex ratio is 2.69.
Pour les six premiers mois de 2014, la moyenne du sexe ratio est de 2,69.
We report contemporaneous changes in previously reported male vs female symptom patterns. Such changes suggest a convergence in which distinctive severity of certain grouped central nervous, emotional, and immune profile items in females have diminished toward that of males. The data also show correlations among these profile items that add further credence to the sex ratio findings. A wider dispersion of the female data as compared with the male data was found in the year preceding the downward trend in the mean sex ratio. The authors suggest that such a trend toward an increase in the variance of the data points to instability in the biological system-the autism spectrum. We conclude that public policy would be better served by monitoring changes in the standard deviation as compared with the mean in large data sets to better anticipate changes.
The findings we report raise questions based on known sex differences in detoxification chemistry. One such question would be whether maternal, fetal, or individual exposure to a novel environmental factor may have breached the taller fence of female protection from toxins.
Les résultats que nous rapportons soulèvent des questions sur la base de différences de sexe connus en chimie de désintoxication. Une question serait de savoir si l'exposition individuelle maternelle ou fœtale à un nouveau facteur environnemental peut avoir enfreint la haute protection de la barrière de protection des femmes contre les toxines.
Une invention en technologie de l'information incorporée dans un site Web servant les intérêts de la communauté de l'autisme a été conçue pour «laisser parler de données."
Par son utilisation, les auteurs ont détecté une tendance temporelle à la baisse en 2013 dans le rapport de masculinité de 2431 membres de Autism360.org d'une moyenne annuelle de 04.24 entre 2010 et 2012 à 03.01 en 2013.
As of the first two months of 2014, the average sex ratio is 2.69.
Pour les six premiers mois de 2014, la moyenne du sexe ratio est de 2,69.
We report contemporaneous changes in previously reported male vs female symptom patterns. Such changes suggest a convergence in which distinctive severity of certain grouped central nervous, emotional, and immune profile items in females have diminished toward that of males. The data also show correlations among these profile items that add further credence to the sex ratio findings. A wider dispersion of the female data as compared with the male data was found in the year preceding the downward trend in the mean sex ratio. The authors suggest that such a trend toward an increase in the variance of the data points to instability in the biological system-the autism spectrum. We conclude that public policy would be better served by monitoring changes in the standard deviation as compared with the mean in large data sets to better anticipate changes.
The findings we report raise questions based on known sex differences in detoxification chemistry. One such question would be whether maternal, fetal, or individual exposure to a novel environmental factor may have breached the taller fence of female protection from toxins.
Les résultats que nous rapportons soulèvent des questions sur la base de différences de sexe connus en chimie de désintoxication. Une question serait de savoir si l'exposition individuelle maternelle ou fœtale à un nouveau facteur environnemental peut avoir enfreint la haute protection de la barrière de protection des femmes contre les toxines.
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