CDC Kerala 13: Facteurs prénataux, nataux et postnataux des enfants (2-6 y) avec autisme - Une étude de cas contrôle

Traduction: G.M.

Indian J Pediatr. 2014 Oct 24. [Epub ahead of print]

CDC Kerala 13: Antenatal, Natal and Postnatal Factors Among Children (2-6 y) with Autism - A Case Control Study

George B¹, Padmam MS, Nair MK, Leena ML, Russell PS.

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Abstract

OBJECTIVES:

To compare antenatal, natal and postnatal factors among children between 2-6 y of age with autism and a control group of normal children.

METHODS:

One hundred and forty three confirmed cases of 2-6 y-old children with autism, attending autism clinic of Child Development Centre, who had a CARS score of ≥ 30 were included in the study. Two hundred normal children in the same age group were recruited from the well-baby/immunization clinic of SAT Hospital, Thiruvananthapuram. Data was collected using a structured pre-piloted questionnaire consisting of 21 antenatal, 8 natal and 6 postnatal risk factors.

RESULTS:

The multivariate analysis on antenatal, natal and postnatal possible risk factors for autism showed statistically significant high odds ratios for (i) excess fetal movement (OR = 11.44; 95 % CI: 2.85 - 45.98); (ii) maternal respiratory infection/asthma (OR = 6.11; 95 % CI: 1.56-24.02; (iii) maternal vaginal infection (OR = 5.20; 95 % CI: 1.72 - 15.73); (iv) maternal hypothyroidism (OR = 4.25; 95 % CI: 1.38-13.07) and (v) family history of neuro-developmental disorders (OR = 2.90; 95 % CI: 1.72 - 4.88).

CONCLUSIONS:

This case control study involving 143 children between 2 and 6 y with autism as per CARS criteria and a control group of 200 normal children has shown that excess fetal movement, maternal respiratory infection/asthma, maternal vaginal infection, maternal hypothyroidism and family history of neuro-developmental disorders are possible risk factors for autism.
Cette étude de cas contrôle impliquant 143 enfants entre 2 et 6 ans avec autisme selon les critères de CARS et un groupe de contrôle de 200 enfants typiques a montré que l'excès de mouvements du fœtus, l'infection des voies respiratoires/asthme de la mère,  l'infection vaginale maternelle, l'hypothyroïdie maternelle et les antécédents familiaux de troubles neuro-developmentaux sont des facteurs de risque possibles de l'autisme. 

PMID: 25338492