Relation entre le sélénium, le plomb et le mercure dans les globules rouges des enfants autistes saoudiens

Aperçu: G.M.

Les données obtenues démontrent une élévation significative du Hg et du Pb ainsi qu'une diminution significative des taux de Se dans les globules rouges des patients avec TSA par rapport aux témoins sans TSA.

Metab Brain Dis. 2017 Mar 21. doi: 10.1007/s11011-017-9996-1.

Relationship between selenium, lead, and mercury in red blood cells of Saudi autistic children

El-Ansary A^1,2,3, Bjørklund G⁴, Tinkov AA^5,6,7, Skalny AV^6,7,8,9, Al Dera H^10,11.

Author information

1

Central Laboratory, Center for Female Scientific and Medical Colleges, King Saud University, Riyadh, Saudi Arabia.

2

Autism Research and Treatment Center, Riyadh, Saudi Arabia.

3

Medicinal Chemistry Department, National Research Centre, Dokki, Cairo, Egypt.

4

Council for Nutritional and Environmental Medicine, Toften 24, 8610, Mo i Rana, Norway. bjorklund@conem.org.

5

Orenburg State University, Orenburg, Russia.

6

Orenburg State Medical University, Orenburg, Russia.

7

Yaroslavl State University, Yaroslavl, Russia.

8

RUDN University, Moscow, Russia.

9

All-Russian Research Institute of Medicinal and Aromatic Plants, Moscow, Russia.

10

Basic Medical Science Department, College of Medicine, King Saud bin Abdul Aziz University for Health Sciences, Riyadh, Saudi Arabia.

11

King Abdullah International Medical Research Center (KAIMRC), Riyadh, Saudi Arabia.

Abstract

Autism spectrum disorder (ASD) is a neurodevelopmental disorder that can cause significant social, communication and behavioral challenges. Environmental contribution to ASD is due in large part to the sensitivity of the developing brain to external exposures such as lead (Pb), and mercury (Hg) as toxic heavy metals or due to a poor detoxification ability as the phenotype of this disorder. Selenium (Se) as an antioxidant element that counteracts the neurotoxicity of Hg, and Pb, presumably through the formation of nontoxic complexes. In the present study, Pb, Hg, and Se were measured in red blood cells (RBCs) of 35 children with ASD and 30 age- and gender-matched healthy control children using atomic absorption spectrometry. Receiver Operating Characteristics (ROC) analysis of the obtained data was performed to measure the predictive value of their absolute and relative concentrations. The obtained data demonstrates a significant elevation of Hg and Pb together with a significant decrease in the Se levels in RBCs of patients with ASD when compared to the healthy controls. The ratios of Se to both Pb and Hg were remarkably altered, being indicative of heavy metal neurotoxicity in patients with ASD. In conclusion, the present study indicates the importance of Se for prevention and/or therapy of heavy metal neurotoxicity.

PMID: 28326463

DOI: 10.1007/s11011-017-9996-1