Auto-immunité, autoanticorps et trouble du spectre de l'autisme

Aperçu: G.M.

De façon alarmante, dans la majorité des cas, les causes des TSA sont largement inconnues.
Bien que les recherches aient porté sur l'identification des anomalies génétiques, les études émergentes suggèrent de plus en plus que le dysfonctionnement immunitaire est un facteur de risque viable contribuant aux déficits neurodéveloppementaux observés dans le TSA.

Biol Psychiatry. 2017 Mar 1;81(5):383-390. doi: 10.1016/j.biopsych.2016.08.031. Epub 2016 Sep 1.

Autoimmunity, Autoantibodies, and Autism Spectrum Disorder

Edmiston E¹, Ashwood P², Van de Water J³.

Author information

1

Division of Rheumatology/Allergy and Clinical Immunology, University of California, Davis, Davis, California; The M.I.N.D. Institute, University of California, Davis, Davis, California.

2

The M.I.N.D. Institute, University of California, Davis, Davis, California; NIEHS Center for Children's Environmental Health, University of California, Davis, Davis, California; Department of Medical Microbiology and Immunology, University of California, Davis, Davis, California.

3

Division of Rheumatology/Allergy and Clinical Immunology, University of California, Davis, Davis, California; The M.I.N.D. Institute, University of California, Davis, Davis, California; NIEHS Center for Children's Environmental Health, University of California, Davis, Davis, California. Electronic address: javandewater@ucdavis.edu

Abstract

Auism spectrum disorder (ASD) now affects one in 68 births in the United States and is the fastest growing neurodevelopmental disability worldwide. Alarmingly, for the majority of cases, the causes of ASD are largely unknown, but it is becoming increasingly accepted that ASD is no longer defined simply as a behavioral disorder, but rather as a highly complex and heterogeneous biological disorder. Although research has focused on the identification of genetic abnormalities, emerging studies increasingly suggest that immune dysfunction is a viable risk factor contributing to the neurodevelopmental deficits observed in ASD. This review summarizes the investigations implicating autoimmunity and autoantibodies in ASD.

Copyright © 2016 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.

PMID: 28340985

DOI: 10.1016/j.biopsych.2016.08.031