Affichage des articles dont le libellé est peptide. Afficher tous les articles
Affichage des articles dont le libellé est peptide. Afficher tous les articles

06 mai 2017

Un essai de croisement contrôlé par placebo de la peptine libérant de la gastrine dans l'enfance dans l'autisme

Aperçu: G.M.
L'objectif de cette étude était d'évaluer l'efficacité, la sécurité et la tolérance du peptide libérant de la gastrine (GRP) par rapport au placebo chez les symptômes du trouble du spectre de l'autisme.
Tous les participants étaient des garçons âgés de 4 à 9 ans.
Il y a eu une réduction des scores de la gamme ABC et de ses sous-échelles après utilisation de GRP et du placebo. La réduction a été plus importante avec le GRP, en particulier dans la sous-échelle «hyperactivité et non-conformité», mais il n'y avait pas de différence statistique entre les résultats  Après une semaine d'injection, 5 enfants ont montré une amélioration de 25% ou plus dans le score total de l'échelle ABC avec l'utilisation de GRP et 2 avec l'utilisation de placebo; Cependant, il n'y avait pas de différence statistique (P = 0,375). Il n'y a eu aucun effet néfaste, aucun changement dans les signes vitaux ou des anomalies de laboratoire associées à l'utilisation de GRP

Clin Neuropharmacol. 2017 Apr 27. doi: 10.1097/WNF.0000000000000213.

A Placebo-Controlled Crossover Trial of Gastrin-Releasing Peptide in Childhood Autism

Author information

1
*Postgraduate Program in Child and Adolescent Health, School of Medicine, Federal University of Rio Grande do Sul; †Department of Pediatrics, Child Neurology Unit, Hospital de Clínicas de Porto Alegre; ‡Department of Internal Medicine, School of Medicine, Cancer and Neurobiology Laboratory, Experimental Research Center, Clinical Hospital (CPE-HCPA), §Department of Pharmacology, Institute for Basic Health Sciences, Cancer and Neurobiology Laboratory, Experimental Research Center, Clinical Hospital (CPE-HCPA), and ∥Department of Pediatrics, Child Neurology Unit, Postgraduate Program in Child and Adolescent Health, School of Medicine, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.

Abstract

OBJECTIVES:

The aim of this study was to evaluate the efficacy, safety, and tolerability of gastrin-releasing peptide (GRP) compared with placebo in autism spectrum disorder symptoms.

METHODOLOGY:

This is a randomized, double-blind, placebo-controlled crossover trial using GRP 160 pmol/kg for 4 consecutive days in 10 children with autism. Outcomes were measured by the Aberrant Behavior Checklist (ABC) scale.

RESULTS:

All participants were boys, aged between 4 and 9 years. There was a reduction in the scores of the ABC range and its subscales after use GRP and placebo. The reduction was more prominent with GRP, particularly in the subscale "hyperactivity and noncompliance," but there was no statistical difference between the results (P = 0.334). After a week of infusion, 5 children showed improvement of 25% or greater in the total score of the ABC scale with GRP use and 2 with placebo use; however, there was no statistical difference (P = 0.375). There were no adverse effects, changes in vital signs, or laboratory abnormalities associated with the use of GRP.

CONCLUSIONS:

The results of this study, despite the small sample size, reinforce previous data on the safety of the GRP in short-term use. There is a need for further research with other designs and a larger sample size to evaluate the efficacy and safety of GRP in children with autism.
PMID: 28452904
DOI: 10.1097/WNF.0000000000000213